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Thus, we can assume that pathways additional to those involved in angiogenesis (Vukojevic et al., 2018) are associated with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway ( Furthermore, we additionally challenged the most immediate period after injury induction (skin defect) (i.e., 2, 5, and 10 min) (Figure 8) due to the evidence that BPC 157 did ensure a particular specificity within the pathways (at least, Egr, Nos, Srf, Vegr, Akt1, Plc , and Kras genes) (Vukojevic et al., 2018)
& Incerpi, M
Collectively, experimental data indicate that BPC-157 exerts coordinated effects on vascular dynamics, connective tissue remodeling, and cellular survival mechanisms
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JCI Insight 5 , e133429 (2020)
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