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In addition to the direct suppression of TYR catalytic activity, other methods for the disruption of melanogenesis include the post-transcriptional control of TYR, regulation of melanosome transfer and the suppression TYR transcription by suppressing upstream signaling pathways

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A total of 176 articles were removed following the exclusion criteria and because they did not meet inclusion criteria due to lack of a controlled design, not meeting the setting characteristics or not meeting the review objective

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