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In CD, characteristic lesions at colonoscopy are deep linear ulcers (rake ulcers) with surrounding erythema and granularity and skip areas of normal-appearing mucosa between areas of involvement (Figure 15.2)

Cross-sectional studies showed that Agathobacter and Prevotella_9 abundance correlated positively with eGFR and negatively with microalbuminuria( 3.1.4.2 Translational difficulties between animal models and human studies Approximately 65% of studies cited in this review are based on animal models (primarily db/db mice and STZ-induced diabetic rats), 25% are human cross-sectional studies, and only 10% are human prospective cohort studies

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