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As we age, our jawbone and gums can shrink, leading to a poor fit for existing dentures

While each component ideally represents an in-focus neuronal soma, the identification process also captures confounding components which can arise from out-of-focus somata, non-somatic structures (e.g., dendrites or blood vessels), or non-biological sources (e.g., fluctuations in background fluorescence), all of which are considered abnormal signals or artifacts

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It took a while to work out what frequency works for me, and over the last couple of years I have found once a month works well for me

An 8-week cycle typically pairs with a 4-week break