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We have taken RB042 into the clinic here in Australia and our team and clinical partners are guiding the study rapidly through the planned SAD and MAD cohorts

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This may be the result of disturbed function of the ThDP-dependent 2-oxoglutarate dehydrogenase (Figure 1), as a universal effect of its inhibition is perturbation in relative amino acid abundance and a subsequent decrease in protein synthesis (196, 197)

similarly, work up gradually from a lower to a higher temperature to build your tolerance