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Metabolic levels associated with MTX resistance In addition to the association between metabolic fold change and MTX resistance, we searched for correlations between metabolic concentration and resistance to MTX (expressed as IC50) at 48 and 96 hours in either the presence or absence of the drug ( Table 1 )

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The S-protein of SARS-CoV-2 has a polybasic insertion (PRRAR) region at the S1/S2 site, which is readily cleaved by furin enzyme 65