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ROS are also essential mediators of angiogenesis, degeneration of extracellular matrix, anti-apoptotic processes, and cellular adhesion processes that participate in the formation and maintenance of endometriotic implants (169)

Pinealon achieves this by stimulating serotonin synthesis through regulation of the 5-tryptophan hydroxylase gene, the rate-limiting enzyme in serotonin production

The net effect is therefore positive, regardless of which pathway dominates

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However studies in both humans and dogs have demonstrated oral supplementation of cyanocobalmin will correct B12 deficiencies (3)