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In one preferred practice of the invention, one or more S-acyl glutathione derivatives is applied in admixture with the dermatologically acceptable carrier or vehicle (e.g., as a lotion, cream, ointment, soap, stick, or the like) so as to facilitate topical application and, in some cases, provide additional therapeutic effects as might be brought about, e.g., by moisturizing of the affected skin areas

Glutathione participates in phase II detoxification by GST-mediated conjugation of electrophiles such as drugs, heavy metals, and lipid peroxides forming mercapturates that are eliminated via MRP/ABCC transporters

Likewise, drug developers therefore engineer analogs with altered amino acids, lipid attachments, or other modifications intended to improve solubility, stability, exposure, and dosing frequency

11 Diabetes, Obesity and Metabolism GI tolerability of incretin therapiesReview of gastrointestinal side effects (nausea, GI discomfort) of GLP-1-based therapies and titration strategies