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Treatment frequency at 3-4 month intervals creates annual costs of $1200-2400 for single-area maintenance or $3200-6000 for multi-area treatments representing substantial ongoing expense requiring budget commitment

Most of the evidence supporting this claim comes from a few observational studies

Puddu A, Mach F, Nencioni A, Viviani GL, Montecucco F (2013) An emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetes

982 DSNPs are required to coordinate benefits between Medicare and Medicaid, and in theory, should improve outcomes for dually eligible individuals compared with nonDSNP Medicare Advantage plans

2017, doi:10.1186/s13321-017-0220-4