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Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug

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Core functions of skeletal cells Osteoblast: Derived from bone marrow mesenchymal stem cells, responsible for synthesizing bone matrix (type I collagen, osteocalcin, bone alkaline phosphatase), promoting calcium and phosphorus deposition, and constructing new bone, it is the core driving force of bone formation