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5c), and enzymatically by NQO1 and/or thioredoxin reductase in addition to FSP1 28,29

Topical and microinfusion-delivered PDRN is the newer application, with literature growing rapidly since 2020

This compartmentalization is likely to be of importance to the therapeutic function of the neurosteroid (150)

The real magic unfolds over 4-8 weeks of treatment, with benefits lasting months to a year

In a longitudinal study of patients with bronchiectasis, NE activity in sputum was significantly associated with airway bacterial load, risk of bronchiectasis exacerbations, pulmonary functional decline, and risk of hospitalization (112)