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These include everolimus, a mechanistic target of rapamycin complex 1 inhibitor that modulates mitochondrial turnover, and idebenone, which bypasses complex I defects to directly transfer electrons

The KELCH domain of the Keap1 homodimer binds to the DLG and ETGE motifs (ETGE acts as a hinge, and DLG acts as a latch) of the Neh2 domain of Nrf2 in the cytosol

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Materials and methods Animals and cell lines GSTM2 knockout mice were prepared by Cyagen Bioscience, Inc