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Kam Ming Ko, [email protected] These authors have contributed equally to this work and share last authorship This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Various lines of experimental evidence have shown that genetic or pharmacological inhibition of SLC7A11 has a pro-survival role in cancer cells under conditions of glucose starvation

Thus, there may be reduced translational potential of some rodent metabolic studies and further research will need to focus on model systems more aligned with human metabolic rates, e.g., resected human cortex or organoid models (Westi et al., 2022

doi: 10.1016/j.tibs.2013.01.004 67 JiangZ.LinJ.DongH.ZhengX.MarjaniS

Reported with higher doses or longer use Mild joint stiffness