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The multifunctional enzyme encoded by the MTHFD1 gene converts 5,10-methylene-THF to 10-formyl-THF which is required for the synthesis of the purine nucleotides

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As discussed in the FY 2023 IPPS/LTCH PPS final rule (87 FR 49048 and 49049), the eligibility and payment processes for the supplemental payment are consistent with the processes for determining eligibility to receive interim and final uncompensated care payments adopted in FY 2014 IPPS/LTCH final rule

Some patients report headache, changes in sleep patterns, mild nausea, or mood fluctuation during the first week

The absence of functional assessments (e.g., epididymal sperm count, motility, viability, and chromatin integrity) limits interpretation of the findings