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The kinase activity of LRRK2 is responsible for phosphorylation of a subset of Rab small GTPase (Steger et al., 2016), which are important for exocytosis of synaptic vesicles, and endolysosomal and Golgi apparatus protein sorting (Bae and Lee, 2020)

Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism

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In addition, their tunable pore size and their readily functionalized surface make them amenable to the loading of a wide range of small-molecule and biologic therapeutics