The nonenzymatic antioxidants include ascorbic acid, glutathione, albumin, -tocopherol, uric acid, and -carotene [4144]
SOS activates Ras, a small guanosine triphosphatase (GTPase), by exchanging guanosine diphosphate (GDP) for guanosine triphosphate (GTP)
Conspicuously diminished expression of GPX4 and NRF2 in psoriatic lesions thereby results in compromised antioxidant capacity and a heightened propensity for ferroptosis, consequently aggravating the breakdown of the epidermal barrier (190, 191)
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The second major mechanism is angiogenesis: the formation of new blood vessels