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The participation of ROS in cancer development is evidenced by the presence of oxidative DNA alteration in tumor tissues

Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine

Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension

(2) Anti-inflammatory effects: Research has shown that glutathione has anti-inflammatory properties, helping to reduce inflammation in the body

Recent studies have demonstrated that these features, which can initiate ferroptosis, are accompanied by the pathogenesis of OA [22, 23, 110]