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It requires beta-oxidation for the conversion of non-toxic into toxic

M., & Amaral, M

When you diet, your fat cells shrink

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More importantly, the dysfunction of Na + /K + -ATPase leads to secondary mitochondrial damage through ion imbalances: intracellular Na + accumulation promotes reverse operation of the sodium-calcium exchanger (NCX), resulting in intracellular calcium overload (85), which is a key potential trigger for mitochondrial structural damage and functional impairment (86)