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In contrast to earlier GLP-1 receptor agonists, which primarily target appetite suppression and glycemic improvement, GLP-3 leverages GCG receptor activation to stimulate lipolysis and elevate basal metabolic rate, thereby contributing to a more pronounced and sustained reduction in adiposity as observed in research models

users often dose it lower or less often than the unmodified form

But its real promise emerged when it was paired with semaglutide producing results that neither drug could achieve alone