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In addition, this work revealed the existence of a second coenzyme, termed triphosphopyridine nucleotide TPN (now widely known as NADP + ), that is required for the oxidation of glucose 6-phosphate to 6-phosphogluconate, by an enzyme which was purified from yeast and erythrocytes and named Zwischenferment [intermediate enzyme now glucose 6-phosphate dehydrogenase (G6PDH)] (Warburg et al., 1935

doi: 10.3389/fphar.2025.1516601 Received 24 October 2024 Accepted 04 February 2025 Published 24 February 2025 Volume 16 - 2025 Edited by Ewa Litwa, Polish Academy of Sciences, Poland Reviewed by Stefano Comai, University of Padua, Italy Archita Venugopal Menon, Beam Therapeutics, United States Updates Copyright 2025 Zhao, Ren, Luo, Li, Cheng, Wen, Wu and Zhou

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Water inflow, water outflow, and changes in water storage are not considered