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Also, its antioxidant properties neutralize free radicals, reducing oxidative stress that can lead to skin darkening and hyperpigmentation

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However, several large randomized controlled trials, including the pivotal study by Moseley et al., and subsequent meta-analyses have demonstrated no long-term benefit over placebo or conservative therapy in terms of pain, function, or disease progression (Moseley et al., 2002)

However, its NADase activity was not investigated [65]