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Abbreviations BMP: bone morphogenetic protein CMap: Connectivity Map COPD: chronic obstructive pulmonary disease CT: computed tomography DLCO: diffusing capacity of carbon monoxide DMEM: Dulbecco's modified Eagle's medium ECM: extracellular matrix FBS: fetal bovine serum FDR: false discovery rate FEV 1 : forced expiratory volume in 1 second FVC: forced vital capacity GOLD: Global Initiative for Chronic Obstructive Lung Disease GSEA: Gene Set Enrichment Analysis Lm: mean linear intercept PBS: phosphate-buffered saline TGF: transforming growth factor Vv: volume fraction

From a pathological perspective, the disease is characterized by the progressive degeneration of both upper motor neurons (UMN) in the cerebral cortex and lower motor neurons (LMN) in the brain stem and spinal cord

Protocol [3] Mice [3] Seven-week old TmcsMed1 -/- mice and the wild-type littermates are then administered Tamoxifen intraperitoneally at a daily dose of 65 mg/kg body weight for 5 days and then killed at selected intervals after initiation of Tamoxifen treatment

Ferrocene was used as an internal standard and reported relative to NHE (Fc/Fc+ = 692 mV vs

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