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Probiotics exert their beneficial effects through various mechanisms, such as competitive inhibition of pathogenic microorganisms, modulation of the gut microbiota, and enhancement of immune functions

It influences the nitric-oxide (NO) system and the dopaminergic and serotonergic systems, which is why anti-inflammatory and gut-brain-axis effects also appear in the literature

These claims frequently rely on small studies conducted several decades ago, uncontrolled patient series or animal experiments using routes and conditions that differ from modern commercial products

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buccal, gingival, sublingual)] or rectal routes are prohibited