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Tobacco use is a worldwide epidemic, claiming the lives of more than 8 million people annually, according to the World Health Organization

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Broadly, TRP channels are transmembrane, cation-selective channels that play a critical role in various cellular processes including muscle contraction, cell proliferation, cell death, gene transcription, and neurotransmitter release, by altering intracellular calcium concentrations [99, 100]

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They have since provided the raw material for a detailed history of black urban life during this critical period of transition