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1130 Identifying new vectors, novel therapeutic targets, and reliable transgenic delivery pathways remains a primary focus in research on gene therapy for NDs

doi: 10.1016/j.mrrev.2006.10.004

During Salmonella Typhimurium infection, C16-carnitine localizes to regions of immune cell destruction, and C16-carnitine acts as a local immunoregulatory molecule that significantly interferes with host immune homeostasis by affecting the number and function of specific immune cell populations, such as T cells and B cells, suggesting that the accumulation of LCACs is part of the pathogen immune evasion strategy [60]

Dermal tissue biopsies taken 24 hours post-injection show residual peptide concentrations at 512% of peak levels, sufficient to maintain gene expression changes initiated during the first-pass exposure