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Pollard and Pomfrett specifically noted no tolerance induction in their work, and the older European clinical data on chronic insomnia models doesnt describe tolerance development either

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Lyophilized peptides are hygroscopic, meaning they actively absorb moisture from the surrounding air

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Frequency of administration In the case wherein the patient's condition does not improve, upon the doctor's discretion the administration of the compounds is administered chronically, that is, for an extended period of time, including throughout the duration of the patient's life in order to ameliorate or otherwise control or limit the symptoms of the patient's disease or condition