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283 Mitochondria in aging and oxidative stress Harman proposed the free radical theory of aging in the 1950s, which hypothesized that the increase of free radicals, especially oxygen free radicals, would induce oxidative stress, causing damage to a variety of bioactive substances and accelerating aging

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Although the literature does not agree on the exact effect of nitrate supplementation on all measures of exercise tolerance, scientists agree that further investigation is needed