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In addition to direct antioxidant responses, it has also been shown that bilirubin can indirectly function to the alleviation of oxidative stress, examples including activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through covalently binding to Kelch-like ECH-associated protein 1 (KEAP1) (54, 61) and thus acting as an antioxidant in the cell

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[DOI] [PubMed] [Google Scholar] 104.Uusijrvi J., Eriksson K., Larsson A.C., Nihln C., Schiffer T., Lindholm P., Weitzberg E

10.1016/j.neuron.2012.07.010 Neuron 155 SandnerB.RiveraF