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247,248,249 Therefore, designing specific ligands to target this pathway can present therapeutic implications in asthma

Pyruvate kinase isozyme M2 (PKM2) is one of the enzymes which are activated by the IGF-1/AKT axis [54, 55] (Fig

220 In the human hepatocyte-derived Huh-7 cell line, treatment with GC-1 upregulated the transcription of mitochondrial carnitine palmitoyl transferase 1a (CPT1a), which is part of a mitochondrial outer membrane fatty acid transfer complex, with a dose-response comparable to that of the native THR ligand, triiodothyronine (T3)

An equal number of individuals of each sex in each group could therefore not be maintained, and both male and female participants were thus included in the analysis