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No peptide can guarantee the prevention of loose skin, especially with very large weight losses or in patients with reduced skin elasticity due to age, genetics, or sun damage

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However, due to its side effects, this treatment has to be performed only by an experienced and trained dermatologist

Angiogenic AcSDKP generation Prolyl oligopeptidase cleaves TB4 and releases the tetrapeptide Ac-Ser-Asp-Lys-Pro, an autonomous angiogenic factor layered on top of TB4's direct effect on endothelial migration

Kinetics measurements The HT adducts were prepared as described previously