As a consequence of this article, we included in our clinical reports a recommendation to check B12 levels prior to the next injection to clarify status
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On my farm, we keep a multi-species B12 solution on hand that can be administered to any species of livestock we have on the farm (we raise sheep, chickens, and pigs, but the solution could also be used for goats and cattle or even domesticated pets)
Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]
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