Dyslipidemia in patients with nonalcoholic fatty liver disease
But these levels naturally decline with age and drop even further in response to chronic stress, inadequate sleep, poor dietary protein intake, heavy alcohol use, and prolonged exposure to environmental pollutants
Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1
Methods 25, 402408 (2001)
doi: 10.1042/bst0370329 251