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Certain foods and activities can cause the sphincter to relax, but GERD may also be caused due to certain physical abnormalities, such as a: However, if diagnostic tests dont reveal any physical abnormalities causing your GERD, your lifestyle choices are probably contributing or causing acid reflux, such as: Acid Reflux can be caused by some medications that you could be on, such as painkillers, which increase acidity in the stomach and antibiotics such as tetracycline, which can directly irritate the esophagus