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Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites and response to mirtazapine in Japanese patients with major depressive disorder (MDD)

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In addition, aging cells show accumulation of metals such as copper and iron, often accompanied by impaired UPR mt and autophagy [155]

In particular, the intestinal flora in a transgenic mouse model of IBD showed an intestinal inflammatory response only when intestinal microbes were present, emphasizing the importance of the intestinal microbiota in IBD (Lloyd-Price et al., 2019)