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A dysfunctional Nrf2 system (low levels, epigenetic changes and mutations) has been linked to elevated risk to develop both vascular diseases such as diabetes, cancer, COPD (regular and CS-induced) and chronic neurovascular diseases such as Parkinsons disease (PD), Alzheimers disease (AD) and ALS [39, 42]

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The guidance was released just in time the following month, the European Commission launched an investigation into allegations that JTI was breaching the menthol ban, after the Swedish government opened an infringement procedure into new types of Camel and Winston cigarettes