[DOI] [PubMed] [Google Scholar] 122.Miles M.P., Andring J.M., Pearson S.D., Gordon L.K., Kasper C., Depner C.M., Kidd J.R
In the present study, the significant reductions of liver and plasma GSH (Table 3) and cystathionine concentrations (Table 2), in addition to the significant correlation between these two compounds, suggested that modulation of the methyl balance and the consequent reduction of Hcy can down-regulate the trans-sulfuration pathway in a dose-dependent response
In addition, since L-theanine was shown to have a relaxing effect and gamma-aminobutyric acid (GABA) was an important inhibitory neurotransmitter, the mixture of L-theanine and GABA had a positive synergistic effect on sleep behavior, including sleep quality and duration in caffeine-induced awake rats, and the mechanism might be that the mixture could promote the expression of GABA receptor, which was conducive to sleep (38)
The pose with the highest frequency was defined as the centroid of the most populated cluster and was extracted as the initial pose for MD simulations
doi: 10.1056/NEJMra1004965 65 GiacomelliRGorlaRTrottaFTirriRGrassiWBazzichiLet al
