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10.1016/j.jphotobiol.2017.10.003 32 GlimeliusB.ManojlovicN.PfeifferP.MosidzeB.KurtevaG.KarlbergM.et al (2018)
For example, the antioxidant response factor NRF2, a bZIP transcription factor that heterodimerizes with small Maf proteins to bind to the AREs, can be targeted by a chimeric molecule termed 'ARE-PROTAC', which successfully induced simultaneous degradation of the NRF2-MafG complex and synergistically suppressed Nrf2 signaling (229)
The primary concerns are the risk of direct mucosal injury to the reduced stomach, unpredictable absorption leading to toxicity or treatment failure, and the increased vulnerability of the gastric remnant to irritation
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