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contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Post-marketing surveillance through the FDA Adverse Event Reporting System (FAERS) and international pharmacovigilance databases continues to monitor for rare or delayed adverse effects

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The activities of 2-OGDDs are affected by the intracellular level of -KG, succinate, fumarate, or 2-HG

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In this regard, oxidative stress is one of the factors that alter mitochondrial dynamics balance, mainly in the direction of fission