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108-173), and extended for another 5-year period by sections 3123 and 10313 of the Affordable Care Act (Pub

Se exerts its primary biological functions through selenoamino acids, which include: (i) defense against OS, (ii) protection of the cellular redox state and signaling, (iii) participation in the metabolism of lipids, and (iv) involvement in thyroid hormone metabolism [119]

This alteration results in the accumulation of toxic metabolites that can adversely affect renal function ( Table 1 ) [84, 85]

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions