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Animal models showing dramatic retinal preservation following peptide treatment may not replicate in humans due to species differences in receptor expression, metabolism, or disease pathology

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doi: 10.1094/MPMI-18-0254

[2] Treated animals showed progressive recovery of tail motor function, absence of autotomy, and resolution of spasticity, alongside electromyographic changes and a microscopic profile in which the vacuolization, white-matter axon loss, gray-matter edema, and motoneuron loss typical of the injury were attenuated