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Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies

Understanding Protein Haptenation Simple Reactivity In its simplest form, protein haptenation results in a single (electrophilic) molecule covalently attached to a side chain of a single (nucleophilic) amino acid in a protein, typically Cys, Lys, His, Arg, and Tyr (Figure 1)

In the course of this, the observations and complaints of the person concerned are recorded