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ROS and antimicrobial activities One of the major factors that leads to the formation of chronic wounds is that of prolonged inflammation and pathogenic infection, which can hamper angiogenesis, stem cell function, and extracellular matrix remodelling 93

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As ionic strength increases (adding salts), this repulsion is shielded, which in some cases can lead to increased aggregation or precipitation of the peptide (especially if the peptide has hydrophobic patches)