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In preclinical studies, HG inhalation mitigated oxidative stress and NLRP3 pyroptosis and HG is shown to decrease both the degree of mitochondrial swelling and loss of mitochondrial membrane potential while also preserving mitochondrial cytochrome c content [9, 31]

For this reason the effective size of a ligand is sometimes rated in terms of either a cone angle of space they are estimated to occupy around the metal (called the Tolman cone angle, it is commonly used to evaluate phosphines' steric bulk) or the in terms of the percentage of the metal's coordination sphere the ligand occupies (called the percent buried volume, it is used to estimate the steric impact of N -heterocyclic carbenes)

Rep 2016, 6, 31597

BMC Pregnancy Childbirth 22, 263

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