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GSH, a pivotal non-enzymatic antioxidant, plays a fundamental role in the elimination of free radicals and the preservation of redox balance

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A study examining time of day variation in contractility response in mesenteric arteries isolated from Wistar rats reported increased NOS3 expression during the active period, which coincided with reduced vasoconstriction in response to phenylephrine and increased vasodilation response to acetylcholine during the active period (Rodrigo and Denniff, 2016)