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Researcher Loren Pickart, PhD, who first isolated GHK from human plasma, described it as having a "profound effect on the reset of human genes toward a more youthful state." More recent genomic analyses confirm that GHK-Cu shifts gene expression patterns in aging tissue toward patterns characteristic of much younger tissue effectively acting as a biological reset at the cellular level

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Coulson RL, Mourrain P, Wang GX (2022) Sleep deficiency as a driver of cellular stress and damage in neurological disorders

References: Pizzorno J

This origin is what places MOTS-c in a separate research category from hGH-fragment or GHRH-analog compounds, since its activity is rooted in mitochondrial biology rather than the pituitary-hormone axis