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Isoquercetin, a quercetin glycoside, was shown to significantly suppress the production of histamine and pro-inflammatory cytokines, such as IL-6, IL-8, IL-1, and tumor necrosis factor (TNF)-, in phorbol-12-myristate 13-acetate plus the calcium ionophore A23187 (PMACI)-stimulated human basophilic KU812 cells

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Use during pregnancy and lactation should be limited to cases where the benefits outweigh the risks, as high-dose parenteral administration has not been fully studied in these populations

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Administration, regardless of being subcutaneous, intramuscular, or oral, requires sterile techniques and proper handling to prevent infection or contamination