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USA 103 , 94829487 (2006)

25 mg/mL) revealed a spectrum of toxic effects, including a dose-dependent reduction in viability, upregulation of oxidative stress-related genes, increased lipid peroxidation, and apoptosis-driven cell death [123]

Traditional antihistamines only block one downstream effect

In addition, this review provided an overview of current therapeutic strategies targeting ROS, including both mitochondria-targeted antioxidants and conventional agents

It is thought to thought to interact with growth factors and cytokines, which are important signaling molecules that regulate cell growth, differentiation, and inflammation