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The significance of iron buildup in inflamed tissue, resulting in cellular toxicity, in autoimmune and autoinflammatory illnesses associated with arthritis, such as OA, remains ambiguous [35]

*Correspondence: Tiziana Crepaldi, [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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However, to deepen our knowledge of eryptosis regulation, investigations aiming at uncovering the role of ion transport in eryptosis should be endorsed