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Massage onto skin and allow to rest 1 to 2 minutes before rinsing

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Experimental investigations show that senescent cells typically exhibit permanent cell cycle arrest mediated by p53/p21 signaling, creating a unique cellular state that depends on specific survival mechanisms for viability

doi: 10.1016/j.molbiopara.2018.02.003 118 ChenJHuXHeSWangLHuDWangXet al