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Other researchers have also confirmed the relevant role of CYP4F2 V433M polymorphism in the pharmacogenetics of coumarin anticoagulants (55,56)

SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials

For IGF-1 LR3, that means there is no validated 'normal-adult' indication at all

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10.1017/s095026881000052x 21 EndoH.HigurashiT.HosonoK.SakaiE.SekinoY.IidaH.et al (2011)